Repositioning of new potential schistosomicidal drugs using chemogenomic strategy

نویسندگان

  • Arthur Scalzitti Duarte
  • José Clecildo Barreto Bezerra
  • Lourival de Almeida Silva
  • Bruno Junior Neves
  • Carolina Andrade
  • Marina Clare Vinaud
  • Clélia Christina Mello Silva
چکیده

Background Schistosomiasis remains a severe problem of public health in developing countries [1]. Several reports show that praziquantel, the drug of choice for treating schistosomiasis, can select Schistosoma mansoni strains resistant to the drug. Thus, developing new drugs against this parasitosis is a highly desirable goal [2]. In this context, enzymes involved in energetic metabolism could represent attractive drug targets for novel anti-schistosome chemotherapies [3,4]. We report a chemogenomic strategy for identification of approved drugs that may be able to interfere with energetic metabolism of the Schistosoma mansoni.

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2014